Intra-cerebral Relapse Following Prolonged Remission after Autologous Stem Cell Transplantation for Multiple Myeloma

Central nervous system (CNS) myeloma is a rare phenomenon, especially so after high-dose therapy (HDT) and stem cell transplantation. We describe a case of isolated CNS relapse of myeloma post autologous transplantation that followed a prolonged progression-free interval. Issues regarding the pathop...

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Bibliographic Details
Published inLeukemia & lymphoma Vol. 43; no. 12; pp. 2399 - 2403
Main Authors Seftel, M.D., Maguire, J., Voss, N., Woodhurst, W.B., Dalal, B.I., Shepherd, J.D.
Format Journal Article
LanguageEnglish
Published United States Informa UK Ltd 01.01.2002
Taylor & Francis
Subjects
Brain Neoplasms - etiology
Cns Relapse
Fatal Outcome
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Multiple Myeloma
Multiple Myeloma - pathology
Multiple Myeloma - therapy
Neoplasm Invasiveness
Recurrence
Remission Induction
Stem Cell Transplantation
Transplantation, Autologous
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Summary:Central nervous system (CNS) myeloma is a rare phenomenon, especially so after high-dose therapy (HDT) and stem cell transplantation. We describe a case of isolated CNS relapse of myeloma post autologous transplantation that followed a prolonged progression-free interval. Issues regarding the pathophysiology and management of this unusual complication are discussed.
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ISSN:1042-8194
1029-2403
DOI:10.1080/1042819021000040125