The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence

Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes...

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Bibliographic Details
Published inChimia Vol. 73; no. 5; p. 374
Main Authors Contu, Lara, Steiner, Silvio, Thiel, Volker, Mühlemann, Oliver
Format Journal Article
LanguageEnglish
Published Switzerland Swiss Chemical Society 29.05.2019
Subjects
Antiviral Agents
Innate immune response
Integrated stress response
Nonsense Mediated mRNA Decay
RNA
Rna virus
Stress granules
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Summary:Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis - 1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Mühlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.2019.374