Two new 5(14)-membered type cyclopeptide alkaloids from root bark of Ziziphus spina-christi (L.) Desf

• Published in: Natural product research Vol. 37; no. 15; pp. 2473 - 2479
• Main Authors: Adam, Ibrahim Abdurrahman, Irshad, Rimsha, Atia-tul-Wahab, Omoboyowa, Damilola Alex, Choudhary, M. Iqbal, Wang, Yan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.08.2023; Taylor & Francis Ltd
• Subjects: Alkaloids; Alkaloids - chemistry; Cyclopeptide alkaloids; Cytotoxicity; HeLa Cells; Humans; NMR; Nuclear magnetic resonance; Peptides, Cyclic - chemistry; Peptides, Cyclic - pharmacology; Plant Bark - chemistry; Rhamnaceae; spectral analysis; Toxicity testing; Tumor cell lines; Ziziphus - chemistry; Ziziphus spina-christi; spectral analysis; Ziziphus spina-christi; Cyclopeptide alkaloids; Rhamnaceae; cytotoxicity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2050227

Six 5(14)-membered ring type of cyclopeptide alkaloids (CPAs), including two undescribed members, 1-hydro,2β-methoxy-mauritine-A (1) and 1-hydro,2α-methoxy-mauritine-A (2), together with four known compounds, mauritine-A (3), mauritine C (4), amphibine-A (5), and amphibine-E (6), were isolated from the root bark of Ziziphus spina-christi (L.) Desf., Their structures were determined by multiple spectral analyses, including UV, IR, 1D NMR, 2D NMR, EI-MS, HR-EI-MS, FAB-MS and ESI-MS, and by comparison with literature. All six CPAs were tested in vitro for cytotoxicity by three human cancer cell lines (MCF7, H460 and Hela) and a human normal cell line (BJ). None of the compounds showed cytotoxicity towards all tested cell lines.