Immunotoxicology of brown recluse spider (Loxosceles reclusa) venom

A purified toxic protein from Loxosceles reclusa venom was assayed for its in vitro effects on the human immunological and blood clotting systems. The toxin caused inhibition of neutrophil chemotaxis, depletion of serum hemolytic complement, prolongation of the activated partial thromboplastin time...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 24; no. 8; pp. 783 - 790
Main Authors Babcock, J.L, Marmer, D.J, Steele, R.W
Format Journal Article
LanguageEnglish
Published England 1986
Subjects
Arthropod Venoms - toxicity
Blood Coagulation - drug effects
Blood Coagulation Factors - metabolism
Hemolysis - drug effects
Humans
Immunity - drug effects
immunology
In Vitro Techniques
Loxosceles reclusa
Neutrophils - drug effects
Neutrophils - enzymology
Partial Thromboplastin Time
Prothrombin Time
Spider Venoms - toxicity
toxicity
venoms
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Summary:A purified toxic protein from Loxosceles reclusa venom was assayed for its in vitro effects on the human immunological and blood clotting systems. The toxin caused inhibition of neutrophil chemotaxis, depletion of serum hemolytic complement, prolongation of the activated partial thromboplastin time and depletion of clotting factors XII, XI, IX and VIII by an average of 44% in human plasma. The prothrombin time of human plasma was also prolonged by 1.5-2.0 sec. No effect of the purified toxin was observed on microbicidal ability of neutrophils, the release of enzymes from neutrophils or the adherence of neutrophils to glass beads.
ISSN:0041-0101
1879-3150
DOI:10.1016/0041-0101(86)90103-0