A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis
A new iridoid, named methylscutelloside ( 1) together with 19 known compounds belonging to the iridoids ( 2– 4), monoterpenoids ( 5), flavonoids ( 6– 8), triterpenoids ( 9– 14), and phenylethanoids ( 15– 20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were eluci...
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Published in | Bioorganic & medicinal chemistry letters Vol. 21; no. 11; pp. 3462 - 3466 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Ltd
01.06.2011
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A new iridoid, named methylscutelloside (
1) together with 19 known compounds belonging to the iridoids (
2–
4), monoterpenoids (
5), flavonoids (
6–
8), triterpenoids (
9–
14), and phenylethanoids (
15–
20) were isolated from the flowers of
Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.
A new iridoid, named methylscutelloside (
1) together with 19 known compounds belonging to the iridoids (
2–
4), monoterpenoids (
5), flavonoids (
6–
8), triterpenoids (
9–
14), and phenylethanoids (
15–
20) were isolated from the flowers of
Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs. |
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Bibliography: | http://dx.doi.org/10.1016/j.bmcl.2011.03.078 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2011.03.078 |