A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis

• Published in: Bioorganic & medicinal chemistry letters Vol. 21; no. 11; pp. 3462 - 3466
• Main Authors: Tai, Bui Huu, Nhiem, Nguyen Xuan, Quang, Tran Hong, Ngan, Nguyen Thi Thanh, Tung, Nguyen Huu, Kim, Yohan, Lee, Jung-Jin, Myung, Chang-Seon, Cuong, Nguyen Manh, Kim, Young Ho
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.06.2011; Elsevier
• Subjects: Animals; Aorta - drug effects; Biological and medical sciences; Buddleja; Buddleja - chemistry; Buddleja officinalis; cell proliferation; Cell Proliferation - drug effects; chemical structure; flavonoids; flowers; Flowers - chemistry; General pharmacology; iridoids; Iridoids - chemistry; Iridoids - pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Methylscutelloside; Molecular Structure; monoterpenoids; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - drug effects; myocytes; nuclear magnetic resonance spectroscopy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; physicochemical properties; Plant Extracts - pharmacology; Platelet derived growth factor; Rats; smooth muscle; triterpenoids; Vascular smooth muscles cells; Asia; China; Buddleja officinalis; Vascular smooth muscles cells; Methylscutelloside; Platelet derived growth factor; Iridoid; Cell proliferation; Rat; Smooth muscle; Medicinal plant; Buddlejaceae; Acetal; Folk medicine; Dicotyledones; Blood vessel; Angiospermae; Aorta; Glycoside; Terpenoid; Flower; Pharmacognosy; Rodentia; Biological activity; Vertebrata; Mammalia; Animal; Plant origin; Isolation; Monoterpene; Spermatophyta; Structural analysis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2011.03.078

A new iridoid, named methylscutelloside ( 1) together with 19 known compounds belonging to the iridoids ( 2– 4), monoterpenoids ( 5), flavonoids ( 6– 8), triterpenoids ( 9– 14), and phenylethanoids ( 15– 20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs. A new iridoid, named methylscutelloside ( 1) together with 19 known compounds belonging to the iridoids ( 2– 4), monoterpenoids ( 5), flavonoids ( 6– 8), triterpenoids ( 9– 14), and phenylethanoids ( 15– 20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.