Pyranocarbazoles from Murraya koenigii (L.) Spreng. as antimicrobial agents

The bioassay guided fractionation of methanolic extract of Murraya koenigii (L.) Spreng. leaves resulted in the isolation of seven pyranocarbazoles. These were evaluated against four bacterial strains and ten Candida sp. including two matched pair of fluconazole sensitive/resistant clinical isolates...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 32; no. 4; pp. 430 - 434
Main Authors Joshi, Trapti, Jain, Tushar, Mahar, Rohit, Singh, Sumit K., Srivastava, Piush, Shukla, Sanjeev K., Mishra, Dipak K., Bhatta, R. S., Banerjee, Dibyendu, Kanojiya, Sanjeev
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 16.02.2018
Taylor & Francis Ltd
Subjects
antibacterial
Antibacterial activity
antifungal
Antimicrobial agents
Bacteria
Bioassays
Biological activity
Candida
carbazole alkaloids
Clinical isolates
Fluconazole
Fractionation
Fungicides
Hydroxylation
Kanamycin
Klebsiella
Klebsiella pneumonia
Murraya koenigii
Pneumonia
Pyranocarbazoles
Strains (organisms)
Streptococcus aureus
Klebsiella pneumonia
antifungal
Pyranocarbazoles
antibacterial
carbazole alkaloids
Streptococcus aureus
Online AccessGet full text

Cover

More Information
Summary:The bioassay guided fractionation of methanolic extract of Murraya koenigii (L.) Spreng. leaves resulted in the isolation of seven pyranocarbazoles. These were evaluated against four bacterial strains and ten Candida sp. including two matched pair of fluconazole sensitive/resistant clinical isolates. Out of seven, three i.e. Koenine (mk279), Koenigine (mk309) and Mahanine (mk347) exhibited significant antibacterial activity MIC90 3.12-12.5 μg/mL against bacterial strains Streptococcus aureus and Klebsiella pneumonia compared with standard drug Kanamycin MIC90 12.5 μg/mL. However, only mk309 was found active against variety of Candida species MIC90 12.5-100 μg/mL. It was observed that hydroxylation at C-6 and C-7 positions in the studied pyranocarbazoles activate the bioactivity. Simultaneously, decrease in Log P value compares with −H and −O−CH3 substituted derivatives. The study is focused on selective antifungal and antibacterial activity of pyranocarbazoles on bacterial strains S. aureus, K. pneumonia and variety of Candida species with structure activity relationship observations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1308363