New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk

Highlights • The hallmark of MDSCs is their ability to suppress T cell and NK cell responses and induce immune tolerance. • MDSCs accumulate at the fetal-maternal interface in healthy pregnancies. • We propose a model in which an increased frequency of MDSCs promotes the establishment of feto-matern...

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Bibliographic Details
Published inJournal of reproductive immunology Vol. 113; pp. 35 - 41
Main Authors Zhao, Ai-Min, Xu, Hai-Jing, Kang, Xiao-Min, Lu, Li-Ming
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.02.2016
Subjects
Female
Feto-maternal cross-talk
Humans
Immunosuppression
Maternal-Fetal Exchange - immunology
Myeloid Cells - immunology
Myeloid-derived suppressor cells
Obstetrics and Gynecology
Pregnancy
Pregnancy Complications - immunology
Pregnancy Complications - pathology
Th2 Cells - immunology
Th2 Cells - pathology
Trophoblasts - immunology
Trophoblasts - pathology
Pregnancy
Immunosuppression
Feto-maternal cross-talk
Myeloid-derived suppressor cells
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Summary:Highlights • The hallmark of MDSCs is their ability to suppress T cell and NK cell responses and induce immune tolerance. • MDSCs accumulate at the fetal-maternal interface in healthy pregnancies. • We propose a model in which an increased frequency of MDSCs promotes the establishment of feto-maternal tolerance during gestation. • New insights into feto-maternal immune cross-talk will facilitate better understanding of the pathogenesis of pregnancy complications and offer the prospect of novel effective interventions.
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ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2015.11.001