Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy diagnosis

• Published in: International ophthalmology Vol. 41; no. 1; pp. 257 - 264
• Main Authors: Orduña-Azcona, Javier, Pérez-Fernández, Elia, Guadilla, Ana M., De Manuel-Triantafilo, Sofía, Modamio, Laura, Gili, Pablo
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.01.2021; Springer Nature B.V
• Subjects: Comparative studies; Computed tomography; Correlation analysis; Correlation coefficient; Correlation coefficients; Diagnosis; Evaluation; Medicine; Medicine & Public Health; Ophthalmology; Optical Coherence Tomography; Original Paper; Sensitivity analysis; Thickness measurement; Sensitivity and specificity; Choroidal thickness; ROC curve; Optical coherence tomography; Central serous chorioretinopathy
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-020-01577-0

Purpose To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis. Methods Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient. Results Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 μm vs. 347.54 ± 111.27 μm, p  < 0.001). The best threshold measure was 390 μm in patients younger than 50 years giving a sensitivity of 89.7% (CI 95%: 73.6–100%) and a specificity of 75% (CI 95%: 40.9–87.3%). For patients older than 50 years best threshold measure was found at 400 μm giving a sensitivity of 45.5% (CI 95%: 21.3–72%) and a specificity of 80% (CI 95%: 58.4–91.9%). Intraclass correlation coefficient for CT measurement was 0.87 (CI 95%: 0.74–0.93). Conclusion CT measurement with EDI-OCT helps to differentiate CSC from other causes of macular subretinal fluid in patients younger than 50 years.