The Incredible ULKs: Autophagy and Beyond

• Published in: Molecular cell Vol. 62; no. 4; pp. 475 - 476
• Main Authors: Zhao, Yan G., Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.05.2016
• Subjects: Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Humans; Mammals; neurons; proteins

Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal basal autophagy. ULK1/2 phosphorylate SEC16A and regulate ER export, expanding the autophagy-independent functions of autophagy proteins. Atg1 i...