The Incredible ULKs: Autophagy and Beyond

Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal basal autophagy. ULK1/2 phosphorylate SEC16A and regulate ER export, expanding the autophagy-independent functions of autophagy proteins. Atg1 i...

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Bibliographic Details
Published inMolecular cell Vol. 62; no. 4; pp. 475 - 476
Main Authors Zhao, Yan G., Zhang, Hong
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.05.2016
Subjects
Animals
Autophagy
Autophagy-Related Protein-1 Homolog
Humans
Mammals
neurons
proteins
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Summary:Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal basal autophagy. ULK1/2 phosphorylate SEC16A and regulate ER export, expanding the autophagy-independent functions of autophagy proteins. Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal basal autophagy. ULK1/2 phosphorylate SEC16A and regulate ER export, expanding the autophagy-independent functions of autophagy proteins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
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ISSN:1097-2765
1097-4164
1097-4164
DOI:10.1016/j.molcel.2016.05.005