Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

Highlights • Nafamostat mesilate (NM) inhibits the expression of proinflammatory mediators. • NM promotes anti-inflammatory mediators expression at some time points. • NM reduces the activation of NLRP3 inflammasome. • NM attenuates the recruitment of inflammatory cells.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 56; pp. 230 - 245
Main Authors Li, Chenhui, Wang, Jing, Fang, Yinquan, Liu, Yuan, Chen, Tao, Sun, Hao, Zhou, Xin-Fu, Liao, Hong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.08.2016
Subjects
Allergy and Immunology
Animals
Behavior, Animal - drug effects
Disease Models, Animal
Guanidines - administration & dosage
Guanidines - pharmacology
Infarction, Middle Cerebral Artery - drug therapy
Infiltration
Inflammasomes - drug effects
Inflammation
Inflammation - drug therapy
Male
Microglia
Microglia - drug effects
Nafamostat mesilate
NF-kappa B - drug effects
NF-κB
NLR Family, Pyrin Domain-Containing 3 Protein - drug effects
NLRP3
Psychiatry
Rats
Rats, Sprague-Dawley
Recovery of Function - drug effects
Serine Proteinase Inhibitors - administration & dosage
Serine Proteinase Inhibitors - pharmacology
Stroke
Thrombin
Thrombin - drug effects
NF-κB
Stroke
Thrombin
NLRP3
Inflammation
Infiltration
Nafamostat mesilate
Microglia
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Summary:Highlights • Nafamostat mesilate (NM) inhibits the expression of proinflammatory mediators. • NM promotes anti-inflammatory mediators expression at some time points. • NM reduces the activation of NLRP3 inflammasome. • NM attenuates the recruitment of inflammatory cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.03.019