Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593

The culture broth of Cerrena sp. A593, which was isolated from Pogostemon cablin, showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D (1) and E (2), along with two kno...

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Published inNatural product research Vol. 34; no. 17; pp. 2430 - 2436
Main Authors Liu, Hong-Xin, Tan, Hai-Bo, Chen, Yu-Chan, Li, Sai-Ni, Li, Hao-Hua, Zhang, Wei-Min
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.09.2020
Taylor & Francis Ltd
Subjects
Biotechnology
Cell culture
Cerrena sp
Cytotoxicity
Endophytes
Fungi
NMR
Nuclear magnetic resonance
Pogostemon cablin
Sesquiterpenoids
Toxicity
Tumor cell lines
Tumors
sesquiterpenoids
Pogostemon cablin
cytotoxicity
Cerrena sp
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Summary:The culture broth of Cerrena sp. A593, which was isolated from Pogostemon cablin, showed potent cytotoxicity against several human tumor cell lines. The following chemical study resulted in the isolation of two new triquinane-type sesquiterpenoids, named cerrenins D (1) and E (2), along with two known compounds plerocybellone A (3) and chloriolin B (4). Their structures were fully assigned with the aid of extensive spectroscopic analysis ( 1 H and 13 C NMR, HSQC, HMBC, 1 H- 1 H COSY, HRESIMS, and IR) and data from the literature. Moreover, cytotoxic activity in vitro of compounds 1-4 were evaluated against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound 1 exhibited weak growth inhibitory activity against all the four tumor cell lines with IC 50 values of 41.01, 14.43, 29.67, 44.32 μM.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1539977