Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia

• Published in: Natural product research Vol. 37; no. 12; pp. 1961 - 1968
• Main Authors: Zhao, Ying-Ying, Li, Yu-Jie, Yu, Xiao-Mei, Su, Qin-Ting, Wang, Li-Wen, Zhu, Yu-Shu, Fu, Yan-Hui, Chen, Guang-Ying, Liu, Yan-Ping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.06.2023; Taylor & Francis Ltd
• Subjects: Animals; anti-HIV effects; anti-inflammatory activities; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antiviral agents; HIV; Human immunodeficiency virus; Hydrocortisone; Inflammation; Leaves; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Monocyclic Sesquiterpenes - chemistry; Monocyclic Sesquiterpenes - pharmacology; morincitrinoid A; Morinda - chemistry; Morinda citrifolia; Nitric oxide; Nitric Oxide - chemistry; RNA-directed DNA polymerase; Sesquiterpenoids; Stems; sesquiterpenoids; morincitrinoid A; Morinda citrifolia; anti-HIV effects; anti-inflammatory activities
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2112577

The phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2-6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2-6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds 1-6 were evaluated in vitro. Compounds 1-6 displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC 50 values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds 1-6 showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC 50 values ranging from 0.16 to 6.29 μM.