Microglia activation is associated with IFN-α induced depressive-like behavior

Highlights • IFN-α induces depressive-like behavior in mice. • IFN-α enhances the expression of MHC-II, CD86, and CD54 in the microglia. • MHC-II and CD86 expression is specifically associated with depressive-like behavior.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 55; pp. 105 - 113
Main Authors Wachholz, Simone, Eßlinger, Manuela, Plümper, Jennifer, Manitz, Marie-Pierre, Juckel, Georg, Friebe, Astrid
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.07.2016
Subjects
Allergy and Immunology
Animals
Behavior, Animal - physiology
CD54
CD86
Depression
Depression - chemically induced
Depression - immunology
Depression - physiopathology
Depressive-like behavior
Disease Models, Animal
Immunologic Factors - administration & dosage
Immunologic Factors - pharmacology
Interferon-alpha
Interferon-alpha - administration & dosage
Interferon-alpha - pharmacokinetics
Male
MHC-II
Mice
Mice, Inbred BALB C
Microglia
Microglia - immunology
Psychiatry
CD86
Interferon-alpha
Depressive-like behavior
Depression
Microglia
MHC-II
CD54
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Summary:Highlights • IFN-α induces depressive-like behavior in mice. • IFN-α enhances the expression of MHC-II, CD86, and CD54 in the microglia. • MHC-II and CD86 expression is specifically associated with depressive-like behavior.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.09.016