Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circ...

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Published inNatural product research Vol. 36; no. 6; pp. 1522 - 1528
Main Authors Li, Lan-Qing, Li, Jing, Long, Hong-Ping, Liu, Ji-Kai, Wang, Xian
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 19.03.2022
Taylor & Francis Ltd
Subjects
Acetic acid
Animals
Ascomycota
Circular dichroism
Deprivation
Dichroism
Ethyl acetate
Fermentation
Liquid chromatography
Neuroprotection
Neuroprotective Agents - pharmacology
neuroprotective effects
PC12 Cells
Pheochromocytoma cells
Rats
Resorcinol
Resorcinols - pharmacology
Xylaria
Xylaria nigripes
Xylariales - chemistry
neuroprotective effects
resorcinol
Xylaria nigripes
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Summary:Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1-3 against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated.
Bibliography:ObjectType-Article-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1897591