Targeting Brain Aminopeptidase A: A New Strategy for the Treatment of Hypertension and Heart Failure

• Published in: Canadian journal of cardiology Vol. 36; no. 5; pp. 721 - 731
• Main Authors: Marc, Yannick, Boitard, Solène Emmanuelle, Balavoine, Fabrice, Azizi, Michel, Llorens-Cortes, Catherine
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2020; Elsevier
• Subjects: Angiotensin II - metabolism; Angiotensin III - metabolism; Animals; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Brain - metabolism; Clinical Trials as Topic; Disulfides - pharmacology; Disulfides - therapeutic use; Glutamyl Aminopeptidase - antagonists & inhibitors; Glutamyl Aminopeptidase - metabolism; Heart Failure - etiology; Heart Failure - prevention & control; Humans; Hypertension - drug therapy; Hypertension - metabolism; Life Sciences; Myocardial Infarction - complications; Renin-Angiotensin System; Sulfonic Acids - pharmacology; Sulfonic Acids - therapeutic use

The pathophysiology of heart failure (HF) and hypertension are thought to involve brain renin-angiotensin system (RAS) hyperactivity. Angiotensin III, a key effector peptide in the brain RAS, provides tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopeptidase A (APA), th...