Novel highly-soluble peptide–chitosan polymers: Chemical synthesis and spectral characterization
Novel water-soluble polymers, N-(γ-propanoyl-valin)-chitosan and N-(γ-propanoyl-aspartic acid)-chitosan, were synthesized by reaction of low molecular weight chitosan with N α-(3-bromopropanoyl)-valine and N α-(3-bromopropanoyl)-aspartic acid, respectively, under mild conditions. Prior to reaction w...
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Published in | Carbohydrate polymers Vol. 64; no. 2; pp. 299 - 305 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
11.05.2006
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Novel water-soluble polymers,
N-(γ-propanoyl-valin)-chitosan and
N-(γ-propanoyl-aspartic acid)-chitosan, were synthesized by reaction of low molecular weight chitosan with
N
α-(3-bromopropanoyl)-valine and
N
α-(3-bromopropanoyl)-aspartic acid, respectively, under mild conditions. Prior to reaction with chitosan, the peptide substituents have been prepared by standard peptide chemistry methods from 3-bromopropanoic acid and the relevant α-amino acid
tert-butyl esters. The chemical structure and physical properties of the novel chitosan derivatives were characterized by
1H NMR and IR spectroscopy. The polymers are highly soluble in a wide pH range, which opens new perspectives for the applications of chitosan-based materials. |
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Bibliography: | http://dx.doi.org/10.1016/j.carbpol.2005.11.040 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2005.11.040 |