ENDOTHELIAL MARKERS IN DIABETES MELLITUS

• Published in: Thrombosis research Vol. 85; no. 1; pp. 63 - 65
• Main Authors: Galajda, Peter, Martinka, Emil, Mokáň, Marián, Kubisz, Peter
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 1997; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Biomarkers; diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - pathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - pathology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Humans; Male; Medical sciences; Middle Aged; pathway inhibitor; Platelet Activation; thrombomodulin; Thrombomodulin - blood; tissue factor; von Willebrand factor; von Willebrand Factor - analysis; vWF, von Willebrand factor; Ca i, intracellular calcium; TFPI, tissue factor pathway inhibitor; PF4, platelet factor 4; tissue factor; TM, thrombomodulin; von Willebrand factor; thrombomodulin; diabetes mellitus; CP, C-peptide; pathway inhibitor; Human; Platelet factor 4; Diabetes mellitus; Tissue factor; Biological marker; Metabolic inhibitor; Willebrand factor; Thrombomodulin; Coagulation factor
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/S0049-3848(96)00222-8

In this study we examined 22 NIDDM patients without vascular complications and 17 age-matched healthy blood donors. Von Willebrand factor (vWF) levels were significantly increased in NIDDM patients compared to healthy blood donors (1.33±0.39 vs 1.01±0.27 IU/ml p=0.006), while thrombomodulin (TM) levels were similar in the both groups. vWF levels correlated with calcium dependent secretion parameters such as C-peptide (r=0.680, p<0.001) and PF4 (r=0.613, p<0.01) and did not correlate with calcium-independent markers of endothelial injury such as TM (r=0.287, p=0.196) and TFPI (r=0.296, p=0.181). Therefore it seems that increased levels of Ca i-dependent endothelial and platelet activation markers may precede the signs of endothelial damage. This hypothesis requires further research. Copyright © 1997 Elsevier Science Ltd