Novel antibacterial polymeric nanocomposite for smart co-delivery of anticancer drugs

• Published in: Artificial cells, nanomedicine, and biotechnology Vol. 45; no. 8; pp. 1509 - 1520
• Main Authors: Zakerzadeh, Elham, Alizadeh, Effat, Samadi Kafil, Hossein, Mohammad Hassanzadeh, Azad, Salehi, Roya, Mahkam, Mehrdad
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2017; Taylor & Francis Ltd
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibacterial polymers; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic drugs; Antitumor agents; Cancer; combination therapy; Conjugation; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug Carriers - pharmacology; Drug delivery; Drug delivery systems; Drug Liberation; dual anticancer drug; Humans; MCF-7 Cells; Methotrexate; Minimum inhibitory concentration; nanocomposite; Nanocomposites; Nanocomposites - chemistry; Nanoparticles - chemistry; Nanotechnology; NMR; Nuclear magnetic resonance; pH effects; Polymers - chemistry; Polymers - pharmacology; Silicon Dioxide - chemistry; stimuli responsive; sustained release; Thermogravimetric analysis; combination therapy; nanocomposite; stimuli responsive; dual anticancer drug; sustained release; Antibacterial polymers
• ISSN: 2169-1401; 2169-141X
• DOI: 10.1080/21691401.2016.1260576

Here a novel antibacterial nanocomposite was developed for combination cancer therapy. The synthesized nanocarrier was characterized by FTIR, 1 H NMR, thermogravimetric analysis (TGA), and FESEM-EDX. Its antibacterial activity was assessed by determining minimum inhibitory concentration (MIC) values. Doxorubicin (DOX) and methotrexate (MTX) conjugation with nanocarrier sustained the release of both drugs with apparent pH-triggered manner. Co-administration of DOX with MTX leads to an efficient anticancer performance to MCF7 cell lines verified by qRT-PCR and MTT assay tests. It was concluded that this novel drug delivery vehicle makes antibacterial and anticancer therapeutic processes proceed spontaneously, representing more efficient drug delivery system in nanomedicine.