Further iridoid glucosides in the genus Manulea (Scrophulariaceae)

• Published in: Phytochemistry (Oxford) Vol. 109; pp. 43 - 48
• Main Authors: Gousiadou, Chrysoula, Kokubun, Tetsuo, Gotfredsen, Charlotte H., Jensen, Søren R.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.01.2015; Elsevier
• Subjects: Biochemistry & Molecular Biology; Chemotaxonomy; Glycosides - chemistry; Glycosides - isolation & purification; Iridoid glucosides; Iridoid Glycosides - chemistry; Iridoid Glycosides - isolation & purification; Iridoids - chemistry; Iridoids - isolation & purification; Life Sciences & Biomedicine; Manulea altissima L; Manulea corymbosa L; Molecular Structure; Phenylethanoid glycosides; Plant Extracts - chemistry; Plant Sciences; Science & Technology; Scrophulariaceae; Scrophulariaceae - chemistry; Secoiridoid glucosides; Manulea corymbosa L; Iridoid glucosides; Secoiridoid glucosides; Scrophulariaceae; Chemotaxonomy; Manulea altissima L; Phenylethanoid glycosides; GLYCOSIDES
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2014.10.004

From two species of the genus Manulea (Scrophulariaceae) was isolated secoiridoid glucosides. In addition an ester of adoxosidic acid named altissimoside was found, as well as terpenoid esters of 6β-hydroxy 8-epi-boschnaloside, named manucoside A and B. [Display omitted] •Secoiridoids were isolated and identified from two species of Manulea.•The iridoid esters altissimoside as well as manucoside A and B were isolated.•Manulea is the only genus of the Scrophulariaceae so far with secoiridoids.•The chemotaxonomy of Scrophulariaceae is discussed. From Manulea altissima (Scrophulariaceae) were isolated five known secoiridoid glucosides sweroside, eustomoside, eustoside, secoxyloganin and secologanoside as well as the 4″-O-rhamnopyranosyl-feruloyl ester of adoxosidic acid, named altissimoside. Also, the caffeoyl phenylethanoid glycoside verbascoside was isolated. In addition two previously unknown terpenoid esters of 6β-hydroxy 8-epi-boschnaloside, named manucoside A and B were isolated from a formerly obtained fraction from the work-up of Manulea corymbosa. The distribution of iridoid glucosides in the Scrophulariaceae is discussed.