Bioguided isolation of N-malonyl-(+)-tryptophan from the fruit of Pithecellobium dulce (Roxb.) Benth. that showed high activity against Hymenolepis nana

• Published in: Natural product research Vol. 35; no. 4; pp. 593 - 599
• Main Authors: López-Angulo, Gabriela, Verdugo-Gaxiola, Sara Elizabeth, Montes-Avila, Julio, Díaz-Camacho, Sylvia Páz, Miranda-Soto, Valentín, Salazar-Salas, Nancy Yareli, Delgado-Vargas, Francisco
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.02.2021; Taylor & Francis Ltd
• Subjects: Animals; Artemia; Artemia - drug effects; Chemical Fractionation; Fabaceae - chemistry; Fractionation; Fruit - chemistry; Fruits; Humans; Hymenolepis; Hymenolepis nana; Hymenolepis nana - drug effects; Hymenolepis nana - physiology; Metabolism; Paralysis; Parasites; parasitosis; Pithecellobium; Pithecellobium dulce; Plant Extracts - pharmacology; Praziquantel; Toxicity; treatment; Tryptophan; Tryptophan - isolation & purification; Tryptophan - pharmacology; parasitosis; treatment; Hymenolepis; Pithecellobium

Pithecellobium dulce is distributed in America and Asia where is widely used in traditional medicine. This study describes the bioguided fractionation of the methanol extract (ME) obtained from the P. dulce fruit that showed in vitro activity against Hymenolepis nana; Artemia salina assay was used t...