New polyacetylenes glycoside from Eclipta prostrate with DGAT inhibitory activity

• Published in: Journal of asian natural products research Vol. 21; no. 6; pp. 501 - 506
• Main Authors: Meng, Xiao, Li, Ban-Ban, Lin, Xin, Jiang, Yi-Yu, Zhang, Le, Li, Hao-Ze, Cui, Long
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 03.06.2019; Taylor & Francis Ltd
• Subjects: Animals; Asteraceae; Carbohydrate Conformation; Chemistry; Chemistry, Applied; Chemistry, Medicinal; DGAT; Diacylglycerol O-acyltransferase; Diacylglycerol O-Acyltransferase - antagonists & inhibitors; Eclipta - chemistry; Eclipta prostrata; Glycosides; Inhibitory Concentration 50; Life Sciences & Biomedicine; Liver - drug effects; Liver - enzymology; Magnetic Resonance Spectroscopy; Organic chemistry; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Plant Stems - chemistry; Polyacetylene; Polyacetylene Polymer - chemistry; Polyacetylene Polymer - pharmacology; polyacetylenic glucosides; Rats; Science & Technology; DIACYLGLYCEROL ACYLTRANSFERASE; DGAT; Eclipta prostrata; polyacetylenic glucosides; Asteraceae
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020.2018.1452914

One new polyacetylene glycoside eprostrata Ⅰ (1), together with seven known compounds (2-8), were isolated from Eclipta prostrata. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated inhibitory activity on DGAT in an in vitro assay. Compounds 1-8 were found to exhibit inhibitory activity of DGAT1 with IC 50 values ranging from 74.4 ± 1.3 to 101.1 ± 1.1 μM.