Brain structure and internalizing and externalizing behavior in typically developing children and adolescents

• Published in: Brain Structure and Function Vol. 225; no. 4; pp. 1369 - 1378
• Main Authors: Andre, Quinn R., Geeraert, Bryce L., Lebel, Catherine
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2020; Springer Nature B.V
• Subjects: Adolescence; Adolescent; Adolescent Behavior - physiology; Adolescent Development - physiology; Adolescents; Anisotropy; Biomedical and Life Sciences; Biomedicine; Brain - anatomy & histology; Brain - physiology; Cell Biology; Child; Child Behavior - physiology; Child Development - physiology; Children; Cingulum; Diffusion Tensor Imaging; Female; Gender; Humans; Limbic system; Limbic System - anatomy & histology; Limbic System - physiology; Magnetic resonance imaging; Male; Mental disorders; Mental health; Neuroimaging; Neurology; Neurosciences; Organ Size; Original Article; Prefrontal cortex; Substantia alba; Substantia grisea; Teenagers; White Matter - anatomy & histology; White Matter - physiology; Pediatric neuroimaging; Externalizing; Internalizing; Diffusion tensor imaging (DTI); Structural magnetic resonance imaging; Mental health
• ISSN: 1863-2653; 1863-2661; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-019-01973-y

Mental health problems often emerge in adolescence and are associated with reduced gray matter thickness or volume in the prefrontal cortex (PFC) and limbic system and reduced fractional anisotropy (FA) and increased mean diffusivity (MD) of white matter linking these regions. However, few studies have investigated whether internalizing and externalizing behavior are associated with brain structure in children and adolescents without mental health disorders, which is important for understanding the progression of symptoms. 67 T1-weighted and diffusion tensor imaging datasets were obtained from 48 typically developing participants aged 6–16 years (37M/30F; 19 participants had two visits). Volume was calculated in the prefrontal and limbic structures, and diffusion parameters were assessed in limbic white matter. Linear mixed effects models were used to compute associations between brain structure and internalizing and externalizing behavior, assessed using the Behavioral Assessment System for Children (BASC-2) Parent Rating Scale. Internalizing behavior was positively associated with MD of the bilateral cingulum. Gender interactions were found in the cingulum, with stronger positive relationships between MD and internalizing behavior in females. Externalizing behavior was negatively associated with FA of the left cingulum, and the left uncinate fasciculus showed an age–behavior interaction. No relationships between behavior and brain volumes survived multiple comparison correction. These results show altered limbic white matter FA and MD related to sub-clinical internalizing and externalizing behavior and further our understanding of neurological markers that may underlie risk for future mental health disorders.