Research progress of post-acute sequelae after SARS-CoV-2 infection

• Published in: Cell death & disease Vol. 15; no. 4; p. 257
• Main Authors: Jiao, Taiwei, Huang, Yuling, Sun, Haiyan, Yang, Lina
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 11.04.2024; Nature Publishing Group
• Subjects: Cell death; Complications; COVID-19; COVID-19 - complications; Cytokines; Disease Progression; Dyspnea; Hospitals; Humans; Immune system; Infections; Mental health; Middle East respiratory syndrome; Neutrophils; Pathogenesis; Proteins; Public health; Pulmonary fibrosis; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Viruses
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-024-06642-5

SARS-CoV-2 has spread rapidly worldwide and infected hundreds of millions of people worldwide. With the increasing number of COVID-19 patients discharged from hospitals, the emergence of its associated complications, sequelae, has become a new global health crisis secondary to acute infection. For the time being, such complications and sequelae are collectively called "Post-acute sequelae after SARS-CoV-2 infection (PASC)", also referred to as "long COVID" syndrome. Similar to the acute infection period of COVID-19, there is also heterogeneity in PASC. This article reviews the various long-term complications and sequelae observed in multiple organ systems caused by COVID-19, pathophysiological mechanisms, diagnosis, and treatment of PASC, aiming to raise awareness of PASC and optimize management strategies.