Characterization, antibacterial activity and antibiotic modifying action of the Caryocar coriaceum Wittm. pulp and almond fixed oil

• Published in: Natural product research Vol. 34; no. 22; pp. 3239 - 3243
• Main Authors: Pereira, Fladson F.G., Feitosa, Maria K. S. B., Costa, Maria do S., Tintino, Saulo R., Rodrigues, Fábio F.G., Menezes, Irwin R. A., Coutinho, Henrique D. M., da Costa, José G.M., de Sousa, Erlânio O.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.11.2020; Taylor & Francis Ltd
• Subjects: Acidity; Aminoglycoside antibiotics; Aminoglycosides; Aminoglycosides - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antibacterial activity; Antibiotics; Chemical composition; E coli; Escherichia coli - drug effects; fatty acid; Fatty acids; Fatty Acids - analysis; Gas Chromatography-Mass Spectrometry; Gram-negative bacteria; Malpighiales - chemistry; Microbial Sensitivity Tests; Minimum inhibitory concentration; Oils & fats; Pequi; Peroxide; Physical properties; Plant Oils - chemistry; Plant Oils - pharmacology; Pulp; Refractivity; Staphylococcus aureus - drug effects; fatty acid; aminoglycosides; antibacterial; Pequi
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2018.1552955

In this study the physicochemical characterization of the pulp and almond fixed oil was carried out; their antibacterial activity and aminoglycoside antibiotic modifying action against standard and multiresistant Gram-positive and -negative bacteria were investigated using the broth microdilution assay. Physical properties such as moisture, pH, acidity, peroxide index, relative density and refractive index indicate stability and chemical quality of the oils. In the GC/MS chemical composition analysis, a high unsaturated fatty acid content and the presence of oleic and palmitic acids were observed in the oils. In the antibacterial assay, more significant results were obtained for Escherichia coli, while other standard and multi-resistant strains presented MIC values ≥ 1024 μg/mL. Furthermore, the fixed oils in association with antibiotics were able to significantly improve antibacterial activity against S. aureus with a reduction in MICs.