Antimicrobial activity and molecular docking studies of a novel anthraquinone from a marine-derived fungus Aspergillus versicolor

A novel anthraquinone, 2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione (1), together with nine known compounds (2-10), were isolated from the fermentation of Aspergillus versicolor derived from deep sea sediment. Their structures were established through spectroscopic methods. Compound 1 exhibite...

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Bibliographic Details
Published inNatural product research Vol. 32; no. 5; pp. 558 - 563
Main Authors Wang, Weiyi, Chen, Ruixuan, Luo, Zhuhua, Wang, Wei, Chen, Jianming
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.03.2018
Taylor & Francis Ltd
Subjects
Anthraquinone
antibacterial
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Aspergillus versicolor
Bacteria
Deep sea
Deep sea environments
Diketones
DNA topoisomerase IV
Drug resistance
Fermentation
Minimum inhibitory concentration
Molecular docking
Waterborne diseases
anthraquinone
antibacterial
Aspergillus versicolor
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Summary:A novel anthraquinone, 2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione (1), together with nine known compounds (2-10), were isolated from the fermentation of Aspergillus versicolor derived from deep sea sediment. Their structures were established through spectroscopic methods. Compound 1 exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of 3.9 and 7.8 μg/mL respectively) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 62.5 μg/mL). Compound 1 was subjected to molecular docking studies for inhibition of topoisomerase IV and AmpC β-lactamase enzymes indicating its usefulness as antimicrobial agent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1329732