A new labdane-type diterpenoid from the leaves of Vitex negundo L

A new labdane-type diterpenoid, named vitexnegundin (1), along with seven known compounds, including vitexilactone (2), vitetrifolin D (3), 13-hydroxy-5(10),14-halimadien-6-one (4), (rel 3S,5S,8R,9R,10S)-3,9-dihydroxy-13(14)-labden-16,15-olide (5), artemetin (6), vitexcarpin (7) and penduletin (8),...

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Published inNatural product research Vol. 35; no. 14; pp. 2329 - 2334
Main Authors Sichaem, Jirapast, Nguyen, Hung-Huy, Nguyen, Van-Huong, Mac, Dinh-Hung, Mai, Dinh-Tri, Nguyen, Hoang-Chuong, Tran, Thi-Ngoc-Mai, Pham, Nguyen-Kim-Tuyen, Nguyen, Huu-Hung, Niamnont, Nakorn, Duong, Thuc-Huy
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 18.07.2021
Taylor & Francis Ltd
Subjects
Antiinfectives and antibacterials
Antimicrobial activity
Crystallography
Diterpenes
Drug resistance
E coli
labdane-type diterpenoid
Methicillin
Staphylococcus infections
Vitex negundo
Vitex negundo L
vitexnegundin
labdane-type diterpenoid
vitexnegundin
antimicrobial activity
Vitex negundo L
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Summary:A new labdane-type diterpenoid, named vitexnegundin (1), along with seven known compounds, including vitexilactone (2), vitetrifolin D (3), 13-hydroxy-5(10),14-halimadien-6-one (4), (rel 3S,5S,8R,9R,10S)-3,9-dihydroxy-13(14)-labden-16,15-olide (5), artemetin (6), vitexcarpin (7) and penduletin (8), were isolated from the leaves of Vitex negundo L. Their structures were elucidated by using spectroscopic methods, X-ray crystallographic analysis and comparison with those reported in the literature. Moreover, all isolated compounds 1-8 were evaluated for their antimicrobial activity against ESBL-producing Escherichia coli strain and methicillin-resistant Staphylococcus aureus.
Bibliography:ObjectType-Article-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1672687