Advances in critical care of the pediatric hematopoietic stem cell transplant patient

• Published in: The Pediatric clinics of North America Vol. 60; no. 3; p. 689
• Main Authors: Chima, Ranjit S, Abulebda, Kamal, Jodele, Sonata
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Acute Lung Injury - etiology; Child; Graft vs Host Disease - etiology; Graft vs Host Disease - prevention & control; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Immunosuppressive Agents - therapeutic use; Infection - etiology; Nervous System Diseases - etiology; Thrombotic Microangiopathies - etiology
• ISSN: 1557-8240
• DOI: 10.1016/j.pcl.2013.02.007

Hematopoietic stem cell transplant (SCT) remains a curative option for a variety of malignant and non-malignant disorders in children. Following transplant a proportion of SCT recipients become critically ill and need intensive care. Critical illness may occur in the setting of transplant complications such as graft versus host disease (GVHD), idiopathic pneumonia syndrome (IPS), veno-occlusive disease (VOD) and transplant associated thrombotic microangiopathy (TA-TMA). Hence, familiarity with recent advances in the transplant process and complications is crucial for the intensivist. This article will highlight common complications encountered in the critically ill SCT recipient.