New insights into p53 functions through its target microRNAs

The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been...

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Published inJournal of molecular cell biology Vol. 6; no. 3; pp. 206 - 213
Main Authors Liao, Jun-Ming, Cao, Bo, Zhou, Xiang, Lu, Hua
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.06.2014
Subjects
Animals
Apoptosis - genetics
Cell Cycle Checkpoints - genetics
Humans
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Neoplasms - genetics
Neoplasms - pathology
p53
Reviews
Signal Transduction
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
人类疾病
信号通路
应激反应
微小RNA
肿瘤抑制基因
miRNA
cancer
tumorigenesis
p53
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Summary:The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been identified as additional downstream players of this pathway. Further studies ofthese miRNAs have revealed their more complicated regulations and functions in executing and/or regulating p53 activity. Here, we review the p53 miRNA targets identified thus far, and discuss how they fine-tune p53 stress responses, mediate the crosstalk between p53 and other signaling pathways, and expand the role of p53 in other human diseases in addition to cancers.
Bibliography:31-2002/Q
miRNA, p53, tumorigenesis, cancer
The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been identified as additional downstream players of this pathway. Further studies ofthese miRNAs have revealed their more complicated regulations and functions in executing and/or regulating p53 activity. Here, we review the p53 miRNA targets identified thus far, and discuss how they fine-tune p53 stress responses, mediate the crosstalk between p53 and other signaling pathways, and expand the role of p53 in other human diseases in addition to cancers.
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ISSN:1674-2788
1759-4685
DOI:10.1093/jmcb/mju018