Secondary metabolites from the Colletotrichum gloeosporioides A12, an endophytic fungus derived from Aquilaria sinensis

• Published in: Natural product research Vol. 32; no. 19; pp. 2360 - 2365
• Main Authors: Liu, Hong-Xin, Tan, Hai-Bo, Chen, Yu-Chan, Li, Sai-Ni, Li, Hao-Hua, Zhang, Wei-Min
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.10.2018; Taylor & Francis Ltd
• Subjects: Antineoplastic Agents - isolation & purification; Aquilaria sinensis; Biotechnology; Cell Line; Cell Line, Tumor; Colletotrichum - chemistry; Colletotrichum gloeosporioides; Cyclohexene; cyclohexene derivative; Cyclohexenes - chemistry; Cyclohexenes - isolation & purification; Cytotoxicity; Data processing; Endophytes; Fungi; Humans; Metabolites; Molecular Structure; Secondary metabolites; Spectrum Analysis; thiazole; Thiazoles - chemistry; Thiazoles - isolation & purification; Thymelaeaceae - microbiology; Tumor cell lines; Tumors; Colletotrichum gloeosporioides; cyclohexene derivative; Aquilaria sinensis; cytotoxicity; thiazole
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2017.1410810

Two new cyclohexene derivatives colletotricones A and B (1 and 2) and a new thiazole derivative colletotricole A (5), along with six known natural metabolites were isolated from the extract of Colletotrichum gloeosporioides A12, an endophytic fungus derived from Aquilaria sinensis. Among them, the colletotricones A and B possess a cyclohexenone skeleton, whereas the colletotricole A is a thiazole derivative. Their structures were fully assigned with the aid of extensive spectroscopic analysis and data from the literature. Moreover, cytotoxic activity in vitro of compounds 1 and 3-9 were evaluated against MCF-7, NCI-H460, HepG-2 and SF-268 tumour cell lines. The new compound 1 exhibited growth inhibitory activity against all the four tumour cell lines with IC 50 values ranging from 15.7 to 46.8 μM.