CT-Based Radiomics Analysis Before Thermal Ablation to Predict Local Tumor Progression for Colorectal Liver Metastases

• Published in: Cardiovascular and interventional radiology Vol. 44; no. 6; pp. 913 - 920
• Main Authors: Taghavi, Marjaneh, Staal, Femke, Gomez Munoz, Fernando, Imani, Farshad, Meek, David B., Simões, Rita, Klompenhouwer, Lisa G., van der Heide, Uulke A., Beets-Tan, Regina G. H., Maas, Monique
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2021; Springer Nature B.V
• Subjects: Ablation; Biomarkers; Cardiology; Colorectal cancer; Computed tomography; Confidence intervals; Feature extraction; Health services; Heat treatment; Image segmentation; Imaging; Learning algorithms; Lesions; Liver; Liver cancer; Machine learning; Medical imaging; Medical prognosis; Medicine; Medicine & Public Health; Metastases; Metastasis; Nuclear Medicine; Optimization; Patients; Radiology; Radiomics; Scientific Paper (other); Survival; Tumors; Ultrasound; Liver ablation; Colorectal cancer; Machine learning; Tomography; Neoplasm metastasis; X-ray computed; Liver neoplasms
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-020-02735-8

Purpose Predicting early local tumor progression after thermal ablation treatment for colorectal liver metastases patients is critical for the decision of subsequent follow-up and treatment. Radiomics features derived from medical images show great potential for prediction and prognosis. The aim is to develop and validate a machine learning radiomics model to predict local tumor progression based on the pre-ablation CT scan of colorectal liver metastases patients. Materials and Methods Ninety patients with colorectal liver metastases (140 lesions) treated by ablation were included in the study and were randomly divided into a training ( n  = 63 patients/ n  = 94 lesions) and validation ( n  = 27 patients/ n  = 46 lesions) cohort. After manual lesion volume segmentation and preprocessing, 1593 radiomics features were extracted for each lesion. Three machine learning survival models were constructed based on (1) radiomics features, (2) clinical features and (3) a combination of clinical and radiomics features to predict local tumor progression free survival. Feature reduction and machine learning modeling were performed and optimized with sequential model-based optimization. Results Median follow-up was 24 months (range 6–115). Thirty-one (22%) lesions developed local tumor progression. The concordance index in the validation set to predict local tumor progression free survival was 0.78 (95% confidence interval [CI]: 0.77–0.79) for the radiomics model, 0.56 (95%CI: 0.55–0.57) for the clinical model and 0.79 (95%CI: 0.78–0.80) for the combined model. Conclusion A machine learning-based radiomics analysis of routine clinical CT imaging pre-ablation could act as a valuable biomarker model to predict local tumor progression with curative intent for colorectal liver metastases patients.