Displacement of primary sensorimotor cortex activation after subcortical stroke: a longitudinal PET study with clinical correlation

Five patients with left striatocapsular infarction were studied twice with PET during auditory-cued right thumb-index tapping, around 2 months after stroke and again around 8 months after stroke. At PET1 and PET2, the ipsilesional primary sensorimotor (SM1) activation peak Talairach coordinates were...

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Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 19; no. 4; pp. 1650 - 1654
Main Authors Calautti, Cinzia, Leroy, Francois, Guincestre, Jean-Yves, Baron, Jean-Claude
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2003
Elsevier Limited
Subjects
Acoustic Stimulation
Brain Mapping
Corpus Striatum - diagnostic imaging
Corpus Striatum - physiopathology
Dominance, Cerebral - physiology
Female
Follow-Up Studies
Hemiplegia - diagnostic imaging
Hemiplegia - physiopathology
Humans
Image Processing, Computer-Assisted - methods
Internal Capsule - diagnostic imaging
Internal Capsule - physiopathology
Male
Medical research
Middle Aged
Motor Cortex - diagnostic imaging
Motor Cortex - physiopathology
Patients
PET
Plasticity
Primary motor cortex
Psychomotor Performance - physiology
Recovery
Somatosensory Cortex - diagnostic imaging
Somatosensory Cortex - physiopathology
Stroke
Studies
Tomography, Emission-Computed - methods
Primary motor cortex
Stroke
Recovery
PET
Plasticity
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Summary:Five patients with left striatocapsular infarction were studied twice with PET during auditory-cued right thumb-index tapping, around 2 months after stroke and again around 8 months after stroke. At PET1 and PET2, the ipsilesional primary sensorimotor (SM1) activation peak Talairach coordinates were compared to those from seven aged-matched healthy controls. At PET1, there was a significant posterior displacement of SM1 activation peak, which confirms a previous report and may represent unmasking/disinhibition of motor representations. Over time, there was no significant change in the coordinates, and no significant correlation between coordinate changes from PET1 to PET2 and concomitant motor recovery. The implications of posterior displacement of SM1 activation peak for recovery therefore remain elusive.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(03)00205-2