Anti-inflammatory constituents from Psychotria prainii H. Lév

One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The...

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Published inNatural product research Vol. 33; no. 5; pp. 695 - 700
Main Authors Tran, Phi Hung, Le, Viet Dung, Do, Thi Ha, Nguyen, Thi Luyen, Nguyen, Phuong Thao, Nguyen, Trong Thong, Nguyen, Tien Dat
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.03.2019
Taylor & Francis Ltd
Subjects
Acids
anti-inflammation
asperulosidic acid
Biological activity
Chemical composition
Ethanol
Inflammation
iridoid
Lipopolysaccharides
obtucarbamates C
Organic chemistry
Psychotria
Psychotria prainii
obtucarbamates C
asperulosidic acid
anti-inflammation
iridoid
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Summary:One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC 50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1408095