Partial hydatidiform mole with diploid karyotype in a live fetus

• Published in: International journal of gynecology and obstetrics Vol. 69; no. 2; pp. 149 - 152
• Main Authors: Lembet, A, Zorlu, C.G, Yalçin, H.R, Seçkin, B, Ekici, E
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.05.2000; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Dandy-Walker Syndrome - diagnostic imaging; Diploid karyotype; Diploidy; Diseases of mother, fetus and pregnancy; Female; Fetal Death; Fetal Diseases - diagnostic imaging; Fetus; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Hydatidiform Mole - diagnosis; Hydatidiform Mole - genetics; Karyotyping; Medical sciences; Partial mole; Pregnancy; Pregnancy. Fetus. Placenta; Ultrasonography, Prenatal; Uterine Neoplasms - diagnosis; Uterine Neoplasms - genetics; Partial mole; Fetus; Diploid karyotype; Human; Trophoblaste pathology; Pregnancy disorders; Hydatidiform mole; Placenta diseases; Case study; Fetal diseases; Diploidy; Placenta; Partial; Cytogenetics; Tumor; Female; Karyotype
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1016/S0020-7292(00)00179-X

Even though most instances of partial mole are triploid, only a few cases of diploid partial moles have been reported. Prognosis of partial mole is usually better than the complete mole as few cases of partial moles progress to persistent trophoblastic disease. However, the nature and the risks of diploid partial moles are not well established and they seem to be a distinct clinical entity. Here we report a case of partial mole presenting with a 22 weeks live fetus and preeclampsia. Fetal blood sampling was performed for cytogenetic analysis which revealed a diploid (46XY) karyotype. No progression to malignant gestational trophoblastic disease occurred.