Pemphigus Foliaceus after COVID-19 Vaccination: A Report of Two Cases

• Published in: Case reports in dermatological medicine Vol. 2023; pp. 1 - 6
• Main Authors: Pham, Nguyen Nhat, Nguyen, Thuy Thi Phan, Vu, Thao Thi Phuong, Nguyen, Hao Trong
• Format: Journal Article
• Language: English
• Published: New York Hindawi 19.10.2023; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Antigens; Autoimmune diseases; B cells; Case Report; Case reports; Coronaviruses; COVID-19 vaccines; Dermatitis; Dermatology; Disease; Family medical history; Histopathology; Hospitals; Hydrochlorothiazide; Immunology; Neutrophils; Pathogenesis; Patients; Pemphigus; RNA; Skin; Skin diseases; Steroids; Vaccination; Valsartan; Iran
• ISSN: 2090-6463; 2090-6471
• DOI: 10.1155/2023/1218388

Autoimmune bullous diseases (AIBDs) following coronavirus disease (COVID-19) vaccination have been previously documented in medical literature, given the comparable nature of the RNA antigen in these vaccines to that of the cellular nuclear matter. However, pemphigus foliaceus has been reported less frequently than other postimmunization AIBDs worldwide. Two women were admitted to our hospital with skin erosion over their faces, trunks, and extremities after receiving COVID-19 vaccination. Upon examination and consultation with pathologists, the diagnosis of pemphigus foliaceus was confirmed for both patients. In an effort to contribute to the knowledge on this intriguing topic, we present these two aforementioned cases of pemphigus foliaceus following COVID-19 vaccination, which may initially appear as a typical occurrence but exhibit some noteworthy characteristics.