Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome
Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitan...
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| Published in | Molecular nutrition & food research Vol. 57; no. 12; pp. 2258 - 2263 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
Blackwell Publishing Ltd
01.12.2013
Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1613-4125 1613-4133 1613-4133 |
| DOI | 10.1002/mnfr.201300280 |
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| Abstract | Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota. |
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| AbstractList | Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota. Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota. |
| Author | Seppänen-Laakso, Tuulikki Nohynek, Liisa Aura, Anna-Marja Oksman-Caldentey, Kirsi-Marja Törrönen, Riitta Tómas-Barberán, Francisco A. Leppänen, Tiina Moilanen, Eeva Puupponen-Pimiä, Riitta Kankainen, Matti Maukonen, Johanna Espín, Juan C. Poutanen, Kaisa Kolehmainen, Marjukka |
| Author_xml | – sequence: 1 givenname: Riitta surname: Puupponen-Pimiä fullname: Puupponen-Pimiä, Riitta email: riitta.puupponen-pimia@vtt.fi organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 2 givenname: Tuulikki surname: Seppänen-Laakso fullname: Seppänen-Laakso, Tuulikki organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 3 givenname: Matti surname: Kankainen fullname: Kankainen, Matti organization: CSC - IT Center for Science Ltd, Espoo, Finland – sequence: 4 givenname: Johanna surname: Maukonen fullname: Maukonen, Johanna organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 5 givenname: Riitta surname: Törrönen fullname: Törrönen, Riitta organization: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland – sequence: 6 givenname: Marjukka surname: Kolehmainen fullname: Kolehmainen, Marjukka organization: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland – sequence: 7 givenname: Tiina surname: Leppänen fullname: Leppänen, Tiina organization: School of Medicine, The Immunopharmacology Research Group, Tampere University Hospital, University of Tampere, Tampere, Finland – sequence: 8 givenname: Eeva surname: Moilanen fullname: Moilanen, Eeva organization: School of Medicine, The Immunopharmacology Research Group, Tampere University Hospital, University of Tampere, Tampere, Finland – sequence: 9 givenname: Liisa surname: Nohynek fullname: Nohynek, Liisa organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 10 givenname: Anna-Marja surname: Aura fullname: Aura, Anna-Marja organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 11 givenname: Kaisa surname: Poutanen fullname: Poutanen, Kaisa organization: VTT Technical Research Centre of Finland, Espoo, Finland – sequence: 12 givenname: Francisco A. surname: Tómas-Barberán fullname: Tómas-Barberán, Francisco A. organization: Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia, Espinardo, Spain – sequence: 13 givenname: Juan C. surname: Espín fullname: Espín, Juan C. organization: Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia, Espinardo, Spain – sequence: 14 givenname: Kirsi-Marja surname: Oksman-Caldentey fullname: Oksman-Caldentey, Kirsi-Marja organization: VTT Technical Research Centre of Finland, Espoo, Finland |
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| Keywords | Endocrinopathy Human Biological fluid Fruit Nutrition Microbiological profiling Berry Gut Metabolic diseases Cardiovascular disease Lipids Microflora Ellagitannin-rich berries Lipidomics Metabolic syndrome Blood Symptomatology Microbiological investigation Urolithins Plant origin Production Clinical trial |
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| References | González-Barrio, R., Truchado, P., Ito, H., Espín, J. C. et al., UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals. J. Agric. Food Chem. 2011, 59, 1152-1162. Smyth, G. K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3, doi: 10.2202/1544-6115.1027. Basu, A., Rhone, M., Lyons, T. J., Berries: emerging impact on cardiovascular health. Nutr. Rev. 2010, 68, 168-177. Gonzáles-Barrio, R., Borges, G., Mullen, W., Crozier, A., Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 2010, 58, 3933-3939. Cerdá, B., Tomás-Barberán, F. A., Espín, J. C., Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts and oak-aged wine in humans: identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227-235. Neto, C. C., Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol. Nutr. Food Res. 2007, 51, 652-664. Maukonen, J., Mättö, J., Satokari, R., Söderlund, H. et al., PCR-DGGE and RT-PCR-DGGE show diversity and short-term temporal stability in Clostridium coccoides - Eubacterium rectale group in human intestinal microbiota. FEMS Microbiol. Ecol. 2006, 58, 517-528. Hidalgo, M., Oruna-Concha, J., Kolida, S., Walton, G. E. et al., Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. J. Agric. Food Chem. 2007, 60, 3882-3890. Topping, D. L., Clifton, P. M., Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81, 1031-1064. Cerdá, B., Periago, P., Espín, J. C., Tomás-Barberán, F. A., Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J. Agric. Food Chem. 2005, 53, 5571-5576. Kolehmainen, M., Mykkänen, O., Kirjavainen, P. V., Leppänen, T. et al., Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol. Nutr. Food Res. 2012, 56, 1501-1510. Larrosa, M., García-Conesa, M. T., Espín, J. C., Tomás-Barberán, F. A., Ellagitannins, ellagic acid and vascular health. Mol. Asp. Med. 2010, 31, 513-539. Nygren, H., Seppänen-Laakso, T., Castillo, S., Hyötyläinen, T. et al., Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol. Biol. 2011, 708, 247-257. Pluskal, T., Castillo, S., Villar-Briones, A., Oresic, M., MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinform. 2010, 11, 395. Rao, V., Snyder, D., Raspberries and human health: a review. J. Agric. Food Chem. 2010, 58, 223871-223883. Mättö, J., Maunuksela, L., Kajander, K., Palva, A. et al., Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome: a longitudinal study in IBS and control subjects. FEMS Immunol. Med. Microbiol. 2005, 43, 213-222. Vendram, S., Guglielmetti, S., Riso, P., Arioli, S. et al., Six-week comsumption of a wild blueberry powder drink increases Bifidobacteria in the human gut. J. Agric. Food Chem. 2011, 59, 12815-12820. 2010; 11 2001; 81 2010; 31 2010; 58 2010; 68 2006; 58 2011; 708 2004; 3 2005; 53 2005; 43 2007; 60 2007; 51 2011; 59 2012; 56 e_1_2_4_3_1 e_1_2_4_2_1 e_1_2_4_5_1 e_1_2_4_4_1 e_1_2_4_7_1 e_1_2_4_6_1 e_1_2_4_9_1 e_1_2_4_8_1 e_1_2_4_10_1 e_1_2_4_11_1 e_1_2_4_12_1 e_1_2_4_13_1 e_1_2_4_14_1 e_1_2_4_15_1 e_1_2_4_16_1 e_1_2_4_18_1 e_1_2_4_17_1 |
| References_xml | – reference: Cerdá, B., Tomás-Barberán, F. A., Espín, J. C., Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts and oak-aged wine in humans: identification of biomarkers and individual variability. J. Agric. Food Chem. 2005, 53, 227-235. – reference: Maukonen, J., Mättö, J., Satokari, R., Söderlund, H. et al., PCR-DGGE and RT-PCR-DGGE show diversity and short-term temporal stability in Clostridium coccoides - Eubacterium rectale group in human intestinal microbiota. FEMS Microbiol. Ecol. 2006, 58, 517-528. – reference: Pluskal, T., Castillo, S., Villar-Briones, A., Oresic, M., MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinform. 2010, 11, 395. – reference: Rao, V., Snyder, D., Raspberries and human health: a review. J. Agric. Food Chem. 2010, 58, 223871-223883. – reference: Larrosa, M., García-Conesa, M. T., Espín, J. C., Tomás-Barberán, F. A., Ellagitannins, ellagic acid and vascular health. Mol. Asp. Med. 2010, 31, 513-539. – reference: Vendram, S., Guglielmetti, S., Riso, P., Arioli, S. et al., Six-week comsumption of a wild blueberry powder drink increases Bifidobacteria in the human gut. J. Agric. Food Chem. 2011, 59, 12815-12820. – reference: Smyth, G. K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3, doi: 10.2202/1544-6115.1027. – reference: Topping, D. L., Clifton, P. M., Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81, 1031-1064. – reference: Mättö, J., Maunuksela, L., Kajander, K., Palva, A. et al., Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome: a longitudinal study in IBS and control subjects. FEMS Immunol. Med. Microbiol. 2005, 43, 213-222. – reference: Gonzáles-Barrio, R., Borges, G., Mullen, W., Crozier, A., Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J. Agric. Food Chem. 2010, 58, 3933-3939. – reference: Basu, A., Rhone, M., Lyons, T. J., Berries: emerging impact on cardiovascular health. Nutr. Rev. 2010, 68, 168-177. – reference: Hidalgo, M., Oruna-Concha, J., Kolida, S., Walton, G. E. et al., Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. J. Agric. Food Chem. 2007, 60, 3882-3890. – reference: Cerdá, B., Periago, P., Espín, J. C., Tomás-Barberán, F. A., Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J. Agric. Food Chem. 2005, 53, 5571-5576. – reference: González-Barrio, R., Truchado, P., Ito, H., Espín, J. 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| SubjectTerms | Bioavailability Biological and medical sciences Blood Pressure - drug effects Clinical trial Coumarins - urine Ellagitannin-rich berries Feeding. Feeding behavior Fragaria Fruit - chemistry Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - drug effects Gastrointestinal Tract - microbiology Humans Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - urine Lipidomics Lipids - blood Medical sciences Metabolic diseases Metabolic Syndrome - diet therapy Metabolic Syndrome - metabolism Metabolic Syndrome - microbiology Microbiological profiling Microbiota Miscellaneous Other metabolic disorders Treatment Outcome Urolithins Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome |
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