Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

• Published in: Molecular nutrition & food research Vol. 57; no. 12; pp. 2258 - 2263
• Main Authors: Puupponen-Pimiä, Riitta, Seppänen-Laakso, Tuulikki, Kankainen, Matti, Maukonen, Johanna, Törrönen, Riitta, Kolehmainen, Marjukka, Leppänen, Tiina, Moilanen, Eeva, Nohynek, Liisa, Aura, Anna-Marja, Poutanen, Kaisa, Tómas-Barberán, Francisco A., Espín, Juan C., Oksman-Caldentey, Kirsi-Marja
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.12.2013; Wiley
• Subjects: Bioavailability; Biological and medical sciences; Blood Pressure - drug effects; Clinical trial; Coumarins - urine; Ellagitannin-rich berries; Feeding. Feeding behavior; Fragaria; Fruit - chemistry; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - microbiology; Humans; Hydrolyzable Tannins - pharmacology; Hydrolyzable Tannins - urine; Lipidomics; Lipids - blood; Medical sciences; Metabolic diseases; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Metabolic Syndrome - microbiology; Microbiological profiling; Microbiota; Miscellaneous; Other metabolic disorders; Treatment Outcome; Urolithins; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Endocrinopathy; Human; Biological fluid; Fruit; Nutrition; Microbiological profiling; Berry; Gut; Metabolic diseases; Cardiovascular disease; Lipids; Microflora; Ellagitannin-rich berries; Lipidomics; Metabolic syndrome; Blood; Symptomatology; Microbiological investigation; Urolithins; Plant origin; Production; Clinical trial
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201300280

Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.