Studies on Benzimidazoles and Related Compounds. III. The Intramolecular Mannich Reaction of 2-Alkylaminomethylbenzimidazoles

The intramolecular Mannich reaction of 2-alkylaminomethylbenzimidazole (II) provided 4-alkyl-1, 3, 4, 5-tetrahydro-1, 3, 6-oxadiazepino [3, 4-a] benzimidazole (III) in a good yield. Moreover, the amine (II) can be regenerated by treatment of III with 15% hydrochloric acid and its mechanism is specul...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 18; no. 6; pp. 1245 - 1248
Main Authors ISHIWATA, SABURO, SHIOKAWA, YOUICHI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1970
Japan Science and Technology Agency
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Summary:The intramolecular Mannich reaction of 2-alkylaminomethylbenzimidazole (II) provided 4-alkyl-1, 3, 4, 5-tetrahydro-1, 3, 6-oxadiazepino [3, 4-a] benzimidazole (III) in a good yield. Moreover, the amine (II) can be regenerated by treatment of III with 15% hydrochloric acid and its mechanism is speculated.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.18.1245