Absolute Risk or Relative Risk? A Study of Intraspecies and Interspecies Extrapolation of Chemical-Induced Cancer Risk

We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in p...

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Bibliographic Details
Published inRisk analysis Vol. 22; no. 1; pp. 141 - 157
Main Authors Kuo, Jeanne, Linkov, Igor, Rhomberg, Lorenz, Polkanov, Michael, Gray, George, Wilson, Richard
Format Journal Article
LanguageEnglish
Published Oxford UK Blackwell Publishing, Inc 01.02.2002
Subjects
Animals
Carcinogens - toxicity
Databases, Factual
Female
health policy
Humans
Hydrocarbons, Chlorinated - toxicity
Male
Mice
Mutagens - toxicity
Neoplasms - chemically induced
Neoplasms, Experimental - chemically induced
Rats
Risk Assessment
science evaluation
Species Specificity
tobacco smoke pollution
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Summary:We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in predicted risk between chemicals exceeds the difference in risks resulting from application of these two models. On the whole, it appears that relative risk is a better model.
Bibliography:ark:/67375/WNG-FW34Q469-B
istex:C3F18C2C8625C0E430601AE3C9D026FB6D5A3C08
ArticleID:RISA012
This was done by using the program MSTAGE, courtesy of E. A. C. Crouch.
ISSN:0272-4332
1539-6924
DOI:10.1111/0272-4332.t01-1-00012