The effects of plant polyphenols on enterotoxigenic Escherichia coli adhesion and toxin binding

• Published in: Livestock science Vol. 133; no. 1; pp. 101 - 103
• Main Authors: Verhelst, R., Schroyen, M., Buys, N., Niewold, T.
• Format: Journal Article Web Resource
• Language: English
• Published: Elsevier B.V 01.09.2010; Amsterdam; New York: Elsevier; Elsevier Science
• Subjects: Animal production & animal husbandry; Bacteria (microorganisms); bacterial adhesion; binding capacity; brush border membrane vesicles; disease control; Enterotoxigenic Escherichia coli; enterotoxins; Escherichia coli; Escherichia infections; feed additives; fimbriae; gangliosides; Heat-labile toxin; Life sciences; Pig; plant extracts; Polyphenol; polyphenols; Productions animales & zootechnie; proteins; Sciences du vivant; Suidae; swine; swine feeding; toxigenic strains; Heat-labile toxin; Polyphenol; Enterotoxigenic Escherichia coli; Pig
• ISSN: 1871-1413; 1878-0490; 1878-0490
• DOI: 10.1016/j.livsci.2010.06.035

Pigs frequently encounter bacterial infections like enterotoxigenic Escherichia coli (ETEC). Due to rising concerns about antibiotic resistance of bacteria, there is a large demand for natural alternatives to combat these ETEC infections. Plant polyphenols have been suggested to reduce both the binding of cholera toxin to the GM1 ganglioside and the adhesion of uropathogenic E. coli to F1 fimbriae . In this study different commercial natural polyphenol extracts were evaluated for their possible effect on ETEC. Out of the three polyphenol extracts tested two exert inhibitory effects on the heat-labile toxin binding and all three extracts reduced the binding of ETEC to brush borders. The presence of protein abolished labile toxin binding properties of polyphenols. This makes it unlikely that these polyphenols could be used as an actual feed additive to combat ETEC caused diarrhea.