Impact of Operative and Peri-operative Factors on the Long-term Prognosis of Primary Liver Cancer Patients Undergoing Hepatectomy

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 36; no. 4; pp. 523 - 528
• Main Author: 徐立宁 徐盈盈 高德伟
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.08.2016; Department of General Surgery, Clinical Division of South Building, Chinese PLA General Hospital, Beijing 100853, China%Department of Internal Medicine, Henan Cancer Hospital, Zhengzhou 450003, China
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Carcinoma, Hepatocellular - virology; Cholangiocarcinoma - blood; Cholangiocarcinoma - pathology; Cholangiocarcinoma - surgery; Cholangiocarcinoma - virology; Disease-Free Survival; Female; HBSAg; Hepatectomy - adverse effects; Hepatitis B Surface Antigens - blood; Hepatitis B virus; Hepatitis B virus - isolation & purification; Hepatitis B virus - pathogenicity; Humans; Liver Neoplasms - blood; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Liver Neoplasms - virology; Male; Medicine; Medicine & Public Health; Middle Aged; Postoperative Complications - blood; Postoperative Complications - pathology; Prognosis; 中国人民解放军; 切除术; 原发性肝癌; 围手术期; 生存率; 肝细胞癌; 预后; influencing factors; hepatectomy; perioperative time; prognosis; primary liver cancer
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-016-1619-2

This study examined the impact of the operative and peri-operative factors on the long-term prognosis of patients with primary liver cancer undergoing hepatectomy. A total of 222 patients with primary liver cancer who underwent hepatectomy were followed up from January 1986 to December 2010 at Chinese PLA General Hospital. The post-operative complication rate was 14.0% for all cases, 13.7% for hepatocellular carcinoma（HCC）, 10.0% for cholangiocarcinoma. The 1-, 3-, 5- and 10-year overall survival rates in patients with primary liver cancer after resection were 76.6%, 57.6%, 41.4%, and 21.0%. The survival rates were significantly higher in the HCC group than in the cholangiocarcinoma group（P=0.000）, in the non-anatomical resection group than in the anatomical resection group（P=0.005）, in the female group than in the male group（P=0.002）, in patients receiving no blood transfusion than in those who were given intra-operative blood transfusion（P=0.000）, in patients whose intra-operative blood loss was less than 400 m L than in those who intra-operatively lost more than 400 m L（P=0.000）. No significant difference was found in the survival rate between the HBs Ag-positive group and the HBs Ag-negative group（P=0.532）. Our study showed that anatomical resection, blood loss and blood transfusion were predictors of poor survival after hepatectomy for primary liver cancer patients, and concomitant hepatitis B virus infection bore no relation with the post-resection survival.