Associating resting-state connectivity with trait impulsivity

• Published in: Social cognitive and affective neuroscience Vol. 12; no. 6; pp. 1001 - 1008
• Main Authors: Angelides, Nicholas H., Gupta, Jayesh, Vickery, Timothy J.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2017
• Subjects: Adolescent; Adult; Caudate Nucleus - diagnostic imaging; Caudate Nucleus - physiopathology; Female; Humans; Impulsive Behavior; Impulsivity; Inhibition (Psychology); Linear Models; Magnetic Resonance Imaging; Male; Neural Pathways - diagnostic imaging; Neural Pathways - physiopathology; Original; Oxygen - blood; Personality; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Putamen - diagnostic imaging; Putamen - physiopathology; Questionnaires; Reward; Ventral Striatum - diagnostic imaging; Ventral Striatum - physiopathology; Young Adult; impulsivity; fMRI; resting state; connectivity; BIS/BAS
• ISSN: 1749-5016; 1749-5024; 1749-5024
• DOI: 10.1093/scan/nsx031

Psychometric research has identified stable traits that predict inter-individual differences in appetitive motivation and approach behavior. Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scales have been developed to quantitatively assess these traits. However, neural mechanisms corresponding to the proposed constructs reflected in BIS/BAS are still poorly defined. The ventral striatum (VS) and orbitofrontal cortex (OFC) are implicated in subserving reward-related functions that are also associated with the BAS. In this study, we examined whether functional connectivity between these regions predicts components of these scales. We employed resting-state functional connectivity and BIS/BAS scores assessed by a personality questionnaire. Participants completed a resting state run and the Behavioral Inhibition and Activation Systems (BIS/BAS) Questionnaire. Using resting-state BOLD, we assessed correlations between two basal ganglia ROIs (caudate and putamen) and bilateral OFC ROIs, establishing single subject connectivity summary scores. Summary scores were correlated with components of BIS/BAS scores. Results demonstrate a novel correlation between BAS-fun seeking and resting-state connectivity between middle OFC and putamen, implying that spontaneous synchrony between reward-processing regions may play a role in defining personality characteristics related to impulsivity.