Genetic variation in solute carrier genes is associated with preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 203; no. 5; pp. 491.e1 - 491.e13
• Main Authors: Morrison, Alanna C., PhD, Srinivas, Sindhu K., MD, MSCE, Elovitz, Michal A., MD, Puschett, Jules B., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.11.2010; Elsevier
• Subjects: African Continental Ancestry Group - genetics; Alleles; Anion Exchange Protein 1, Erythrocyte - genetics; Biological and medical sciences; Diseases of mother, fetus and pregnancy; European Continental Ancestry Group - genetics; Female; Genetic Association Studies; Genetic Variation; genetics; Genotype; Gynecology. Andrology. Obstetrics; Haplotypes; Humans; Medical sciences; Obstetrics and Gynecology; Odds Ratio; Organic Anion Transporters - genetics; Phenotype; Polymorphism, Single Nucleotide; Pre-Eclampsia - genetics; preeclampsia; Pregnancy; Pregnancy. Fetus. Placenta; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers - genetics; solute carrier; transporters; genetics; preeclampsia; transporters; solute carrier; Pregnancy disorders; Gene; Gynecology; Preeclampsia; Genetics; Obstetrics; Pregnancy toxemia
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2010.06.004

Objective The objective of the study was to evaluate allelic variation in 26 members of the solute carrier (SLC) gene family for an association with preeclampsia. Study Design Preeclampsia cases were women with mild or severe preeclampsia. Controls were enrolled from women without hypertension-related complications who presented for delivery at term (≥37 weeks). The association between preeclampsia and SLC gene single-nucleotide polymorphisms (SNPs) and haplotypes was evaluated by logistic regression models. Results Rs4957061 in SLC9A3 was significantly associated with a reduced risk of preeclampsia in whites (T allele, P = .002; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.16–0.67). For SLC4A1 in blacks, the G allele of rs2074107 ( P = .004; OR, 1.56; 95% CI, 1.15–2.12) and the A allele of rs2857078 ( P < .001; OR, 1.67; 95% CI, 1.27–2.17) were significantly associated with preeclampsia. Also in blacks, rs10066650 in SLCO4C1 (G allele, P = .002; OR, 1.72; 95% CI, 1.21–2.46) was significantly associated with increased risk. Sliding window haplotype analyses identified significantly associated haplotypes in these genes. Conclusion SNPs and haplotypes in SLC9A3 in whites and SLC4A1 and SLCO4C1 in blacks are significantly associated with preeclampsia.