Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies
Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastr...
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| Published in | World journal of gastroenterology : WJG Vol. 21; no. 11; pp. 3174 - 3183 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Baishideng Publishing Group Inc
21.03.2015
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| Online Access | Get full text |
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| Abstract | Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB’s function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB’s role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. |
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| AbstractList | Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-κB’s function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-κB’s role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. |
| Author | Sahil Gambhir Dinesh Vyas Michael Hollis Apporva Aekka Arpita Vyas |
| AuthorAffiliation | Department of Surgery,College of Human Medicine,Michigan State University Department of Pediatrics,College of Human Medicine - Michigan State University |
| Author_xml | – sequence: 1 givenname: Sahil surname: Gambhir fullname: Gambhir, Sahil organization: Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States – sequence: 2 givenname: Dinesh surname: Vyas fullname: Vyas, Dinesh organization: Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States – sequence: 3 givenname: Michael surname: Hollis fullname: Hollis, Michael organization: Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States – sequence: 4 givenname: Apporva surname: Aekka fullname: Aekka, Apporva organization: Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States – sequence: 5 givenname: Arpita surname: Vyas fullname: Vyas, Arpita organization: Sahil Gambhir, Dinesh Vyas, Michael Hollis, Apporva Aekka, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25805923$$D View this record in MEDLINE/PubMed |
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| Notes | Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB’s function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB’s role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. Gastrointestinal cancer;Inflammation;Nuclear facto Sahil Gambhir;Dinesh Vyas;Michael Hollis;Apporva Aekka;Arpita Vyas;Department of Surgery,College of Human Medicine,Michigan State University;Department of Pediatrics,College of Human Medicine - Michigan State University ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Author contributions: Gambhir S and Vyas D contributed equally to this work; Gambhir S and Vyas D designed research; analyzed data and wrote the paper; Hollis M contributed in research and editing; Vyas A contributed in data and conceptualization; Aekka A contributed in editing. Correspondence to: Dinesh Vyas, MD, MS, FICS, FACS, Department of Surgery, College of Human Medicine, Michigan State University, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48912, United States. dinesh.vyas@hc.msu.edu Telephone: +-517-2672491 Fax: +1-517-2672488 |
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| Snippet | Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms... Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms... |
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| SubjectTerms | Animals Anti-Inflammatory Agents - therapeutic use cancer;Inflammation;Nuclear Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology facto Gastrointestinal Gastrointestinal Neoplasms - etiology Gastrointestinal Neoplasms - immunology Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gastrointestinal Neoplasms - prevention & control Humans Inflammation - complications Inflammation - drug therapy Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammation Mediators - immunology Inflammation Mediators - metabolism NF-kappa B - immunology NF-kappa B - metabolism Prognosis Review Risk Factors Signal Transduction |
| Title | Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies |
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