Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies

Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastr...

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Published inWorld journal of gastroenterology : WJG Vol. 21; no. 11; pp. 3174 - 3183
Main Authors Gambhir, Sahil, Vyas, Dinesh, Hollis, Michael, Aekka, Apporva, Vyas, Arpita
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 21.03.2015
Subjects
Animals
Anti-Inflammatory Agents - therapeutic use
cancer;Inflammation;Nuclear
Cell Transformation, Neoplastic - immunology
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
facto
Gastrointestinal
Gastrointestinal Neoplasms - etiology
Gastrointestinal Neoplasms - immunology
Gastrointestinal Neoplasms - metabolism
Gastrointestinal Neoplasms - pathology
Gastrointestinal Neoplasms - prevention & control
Humans
Inflammation - complications
Inflammation - drug therapy
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Inflammation Mediators - immunology
Inflammation Mediators - metabolism
NF-kappa B - immunology
NF-kappa B - metabolism
Prognosis
Review
Risk Factors
Signal Transduction
Gastrointestinal cancer
Inflammation
Nuclear factor kappa B
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Summary:Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB’s function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB’s role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.
Bibliography:Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB’s function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB’s role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.
Gastrointestinal cancer;Inflammation;Nuclear facto
Sahil Gambhir;Dinesh Vyas;Michael Hollis;Apporva Aekka;Arpita Vyas;Department of Surgery,College of Human Medicine,Michigan State University;Department of Pediatrics,College of Human Medicine - Michigan State University
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Author contributions: Gambhir S and Vyas D contributed equally to this work; Gambhir S and Vyas D designed research; analyzed data and wrote the paper; Hollis M contributed in research and editing; Vyas A contributed in data and conceptualization; Aekka A contributed in editing.
Correspondence to: Dinesh Vyas, MD, MS, FICS, FACS, Department of Surgery, College of Human Medicine, Michigan State University, 1200 East Michigan Avenue, Suite 655, East Lansing, MI 48912, United States. dinesh.vyas@hc.msu.edu
Telephone: +-517-2672491 Fax: +1-517-2672488
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i11.3174