Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells

• Published in: Oncology letters Vol. 15; no. 3; pp. 3719 - 3725
• Main Authors: Wang, Nan, Li, Yong, Zhou, Jianhong
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Apoptosis; Care and treatment; Cervical cancer; Development and progression; Gene expression; Genetic aspects; Health aspects; Human papillomavirus; Kinases; Oncology; Oxidoreductases; Ribonucleotide reductase; Studies; United States > US; China; apoptosis; RRM2; tumorigenesis; cell proliferation; cell cycle arrest

Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration. Previous studies have suggested that the expression of RRM2 plays critical roles in tumorigenesis in several cancer types....