Downregulation of ribonucleotide reductase subunits M2 induces apoptosis and G1 arrest of cervical cancer cells

• Published in: Oncology letters Vol. 15; no. 3; pp. 3719 - 3725
• Main Authors: Wang, Nan, Li, Yong, Zhou, Jianhong
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Apoptosis; Care and treatment; Cervical cancer; Development and progression; Gene expression; Genetic aspects; Health aspects; Human papillomavirus; Kinases; Oncology; Oxidoreductases; Ribonucleotide reductase; Studies; United States > US; China; apoptosis; RRM2; tumorigenesis; cell proliferation; cell cycle arrest
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2018.7806

Ribonucleotide reductase subunit M2 (RRM2) is associated with the biological behaviours of cancers, including apoptosis, cell proliferation, invasion, cell cycle and migration. Previous studies have suggested that the expression of RRM2 plays critical roles in tumorigenesis in several cancer types. However, the precise molecular mechanism remains unknown. We previously identified RRM2 as a novel downstream target that is activated by human papillomavirus E7, which activates the extracellular signal-regulated kinase 1/2 signalling pathway, but further studies are warranted to establish RRM2 as a therapeutic target. The results of the present study indicate that RRM2 is associated with cervical cancer cell apoptosis and proliferation. The downregulation of RRM2 significantly increased apoptosis, promoted cell cycle arrest at the G1 phase and inhibited tumour formation in nude mice transplant models . These results highlight the potential for inhibition of RRM2 expression as a promising therapeutic target for human cervical cancer treatment.