Cushing's syndrome as a paraneoplastic feature of renal cell carcinoma: A case report

Cushing's syndrome has been believed to be a paraneoplastic syndrome of renal cell carcinomas. However, there appears to be a dearth of compelling evidence to substantiate this notion. The only eligible documentation of Cushing's syndrome due to ectopic adrenocorticotropic hormone secretio...

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Published inUrology case reports Vol. 50; p. 102504
Main Authors Moradi, Asaad, Abian, Nasrollah, Shakiba, Behnam, Moradi, Kiarash, Arefian, Leyla
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2023
Elsevier
Subjects
ACTH
Cushing's syndrome
Oncology
Paraneoplastic syndrome
RCC
ACTH
Cushing's syndrome
Paraneoplastic syndrome
RCC
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Summary:Cushing's syndrome has been believed to be a paraneoplastic syndrome of renal cell carcinomas. However, there appears to be a dearth of compelling evidence to substantiate this notion. The only eligible documentation of Cushing's syndrome due to ectopic adrenocorticotropic hormone secretion by renal cancer in English literature dates back to 1988, and it pertains to a deceased patient discovered during an autopsy. Here, we present the first case of Cushing's syndrome as a paraneoplastic feature of renal cancer which showed complete resolution following surgical removal of the tumor. Additionally, we conduct review of the literature on this particular subject. •Data supporting Cushing's syndrome as paraneoplastic syndrome of renal cancer are scarce.•Renal cancer might cause Cushing's syndrome by producing ectopic ACTH.•Paraneoplastic Cushing's syndrome may be relieved after partial nephrectomy as happened in our case report.
ISSN:2214-4420
2214-4420
DOI:10.1016/j.eucr.2023.102504