Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices

• Published in: World journal of gastroenterology : WJG Vol. 20; no. 24; pp. 7964 - 7970
• Main Authors: Hu, Xing-Rong, Cui, Xian-Nian, Hu, Qi-Tuo, Chen, Jun
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.06.2014
• Subjects: Adult; Biomarkers - blood; Biopsy; Case-Control Studies; cirrhosis; Collagen Type III - blood; Collagen Type IV - blood; Diffusion Magnetic Resonance Imaging; Diffusion-weighted; Disease Progression; Female; Humans; Hyaluro; Hyaluronic Acid - blood; imaging; Laminin - blood; Liver; Liver - metabolism; Liver - pathology; Liver Cirrhosis - blood; Liver Cirrhosis - diagnosis; Liver Cirrhosis - pathology; Male; Middle Aged; Observational Study; Predictive Value of Tests; Procollagen - blood; Prognosis; Severity of Illness Index; Young Adult; Diffusion-weighted imaging; Biological marker; Laminin; Hyaluronic acid; Liver cirrhosis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v20.i24.7964

AIM:To compare apparent diffusion coefficient(ADC)values on diffusion-weighted imaging(DWI)of hepatic fibrosis patients with those of healthy controls and to identify their correlations with serum indices of liver fibrosis.METHODS:Hyaluronic acid(HA),laminin(LN),typeⅢprocollagen(PCⅢ),and collagen typeⅣ(Ⅳ-C)were measured in 54 hepatic fibrosis patients and 23normal controls,and ADC values were determined on DWI at different b values(b=300,500,700 s/mm2).Correlations between serum indices and ADC values at different liver fibrosis stages were examined,and each index variation of liver fibrosis in different stages were compared,and correlation analysis of each index and the staging of liver fibrosis carried out,and the correlation of each index performed.RESULTS:With progressive liver fibrosis,HA,PCⅢ,andⅣ-C levels increased(P<0.01).As the b value increased,the ADC value decreased gradually with the hepatic fibrosis stages.In different groups with b values of 500 s/mm2 and 700 s/mm2,the ADC value decreased significantly as liver fibrosis progressed(P<0.01).With b values of 500 s/mm2 and 700 s/mm2,there were negative correlations between ADC and LN,PCⅢ,HA,andⅣ-C.This pattern was observed only for HA andⅣ-C at a b value of 300 s/mm2.CONCLUSION:Serum indices of liver fibrosis and ADC values are useful for diagnosing liver fibrosis,with some correlations among them.