Determination of mycophenolic acid plasma levels in renal transplant recipients co-administered sirolimus: comparison of an enzyme multiplied immunoassay technique (EMIT) and liquid chromatography-tandem mass spectrometry

• Published in: Therapeutic drug monitoring Vol. 28; no. 2; p. 274
• Main Authors: Prémaud, Aurélie, Rousseau, Annick, Picard, Nicolas, Marquet, Pierre
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: Area Under Curve; Chromatography, Liquid - methods; Creatinine - blood; Drug Monitoring - methods; Enzyme Inhibitors - blood; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - therapeutic use; Enzyme Multiplied Immunoassay Technique; Graft Rejection - prevention & control; Humans; Kidney Transplantation; Mass Spectrometry - methods; Mycophenolic Acid - blood; Mycophenolic Acid - pharmacokinetics; Mycophenolic Acid - therapeutic use; Sirolimus - blood; Sirolimus - pharmacokinetics; Sirolimus - therapeutic use; Time Factors

This study was designed to compare the enzyme multiplied immunoassay technique (EMIT) and a specific ;liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of mycophenolic acid (MPA) concentrations in plasma samples collected from renal transplant patients receiving...